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Development and applications of functional gene microarrays in the analysis of the functional diversity

Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 1,   Pages 1-20 doi: 10.1007/s11783-011-0301-y

Abstract: Functional gene arrays (FGAs) are a special type of microarrays containing probes for key genes involvedin microbial functional processes, such as biogeochemical cycling of carbon, nitrogen, sulfur, phosphorusGeoChips are considered as the most comprehensive FGAs.Several generations of GeoChip have been developed and applied to investigate the functional diversity

Keywords： functional gene arrays (FGAs)     GeoChip     microbial communities     functional diversity/composition/structure    

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Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Frontiers of Medicine doi: 10.1007/s11684-023-1008-8

Abstract: Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent genechromatin immunoprecipitation sequencing (ChIP-seq), we investigated structural reorganization and functionalWe observed that the chromosomal compartment A/B switch was correlated with CTCF binding levels and genecontain multiple transcription factor binding motifs, acted as a central element to regulate aberrant geneCollectively, our data offer the landscape of hierarchical layers of cancer genome and functional alterations

Keywords： 3D genome     cancer     TADs     loop     gene regulation    

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Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 93-98 doi: 10.1007/s11684-007-0018-2

Abstract: lymphomas and reactive lymph node hyperplasia, and to perform an initial bioinformatic analysis on a novel genelymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with GeneInitial bioinformatic analysis was then performed on a novel gene named KIAA0372, whose function hasand genomic location, its product s physical and chemical properties, subcellular localization and functionalUsing Gene Expression Chips, many differentially expressed genes were uncovered.

Keywords： bioinformatic analysis     functional     KIAA0372     detection     Microarray    

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FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OFTHE FNC GENE

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: population was generated by crossing IL4-4 with M82 to genetically characterize the FNC geneand this showed that a single dominant gene determined fruit netted-cracking.Sequencing and annotation analysis show that FNC(Solyc04 g082540) was the most likely candidate geneFunctional characterization of FNC by overexpressing FNCAC netted-cracking phenotype, suggesting that the FNC transcript level results in the functional

Keywords： fine mapping / fruit netted-cracking / introgression line / transcript level    

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Engineering the grain boundary: a promising strategy to configure NiCoPO/NiCoP nanowire arrays for ultra-stable

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 8,   Pages 1259-1267 doi: 10.1007/s11705-021-2132-0

Abstract: NiCoP4O12/NiCoP nanorod-like arrays with tunable grain boundary density and poresThe optimized NiCoP4O12/NiCoP arrays have a high specific capacitance of 507.810000 cycles, was achieved in an asymmetric cell assembled of the NiCoP4O12/NiCoP arrayswere higher than those of other work, demonstrating as-prepared NiCoP4O12/NiCoP arrays

Keywords： NiCo     array electrode     grain boundary     stability     supercapacitor    

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Erratum to: Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen

Shenghua Ye, Gaoren Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 845-845 doi: 10.1007/s11705-019-1879-z

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Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1134-1146 doi: 10.1007/s11705-020-2014-x

Abstract: The exploration of cost-effective, high-performance, and stable electrocatalysts for the hydrogen evolution reaction (HER) over wide pH range (0–14) is of paramount importance for future renewable energy conversion technologies. Regulation of electronic structure through doping vanadium atoms is a feasible construction strategy to enhance catalytic activities, electron transfer capability, and stability of the HER electrode. Herein, V-doped NiCoP nanosheets on carbon fiber paper (CFP) (denoted as V -NiCoP/CFP) were constructed by doping V modulation on NiCoP nanosheets on CFP and used for pH-universal HER. Benefiting from the abundant catalytic sites and optimized hydrogen binding thermodynamics, the resultant V -NiCoP/CFP demonstrates a significantly improved HER catalytic activity, requiring overpotentials of 46.5, 52.4, and 85.3 mV to reach a current density of 10 mA·cm in 1 mol·L KOH, 0.5 mol·L H SO , and 1 mol·L phosphate buffer solution (PBS) electrolytes, respectively. This proposed cation-doping strategy provides a new inspiration to rationally enhance or design new-type nonprecious metal-based, highly efficient, and pH-universal electrocatalysts for various energy conversion systems.

Keywords： hydrogen evolution reaction     transition metal phosphides     pH-universal     vanadium doping     carbon fiber paper    

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Nickel nanopore arrays as promising current collectors for constructing solid-state supercapacitors with

Huaping Zhao, Long Liu, Yaoguo Fang, Ranjith Vellacheri, Yong Lei

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 339-345 doi: 10.1007/s11705-018-1699-6

Abstract:

In this work, nickel nanopore arrays with a highly-oriented nanoporous structure inherited from porous

Keywords： supercapacitor     ultrahigh rate     metallic nanopore arrays     current collectors     PEDOT    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Construction of NiCoO nanoflake arrays on cellulose-derived carbon nanofibers as a freestanding electrode

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 6,   Pages 691-703 doi: 10.1007/s11705-022-2268-6

Abstract: The NiCo2O4 nanoflake arrays are grown uniformly on the cellulose-based carbonThe as-prepared cellulose-based carbon nanofibers/NiCo2O4 nanoflake arrays are

Keywords： cellulose     carbon nanofibers     NiCo2O4     supercapacitors    

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Fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1425-1437 doi: 10.1007/s11705-022-2163-1

Abstract: Here, we highlight examples of fluorescent probes and functional materials for biological applications

Keywords： fluorescent probes     imaging     cell     biomedicine     biomolecules    

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Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen evolution reaction

Shenghua Ye, Gaoren Li

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 473-480 doi: 10.1007/s11705-018-1724-9

Abstract:

The polypyrrole(PPy)@NiCo hybrid nanotube arrays have been successfully fabricated as a high performanceenhance the turnover frequency of catalysts, the electrocatalytic performance of PPy@NiCo hybrid nanotube arrays

Keywords： NiCo alloy     polypyrrole     hybrid nanotube     electrocatalyst     hydrogen evolution reaction    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 321-330 doi: 10.15302/J-FASE-2014037

Abstract: Among them, the gene is merely 87 bp away from the significant SNP, Hapmap30383-BTC-005848., we report herein genotype-phenotype associations to further validate the genetic effects of the gene

Keywords： GWAS     functional annotation     Chinese Holstein     milk production traits     C14H8orf33 gene     single nucleotide    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract: We propose that the resistance gene flow in nature is “from the natural environments” andand animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Title Author Date Type Operation

Development and applications of functional gene microarrays in the analysis of the functional diversity

Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU

Journal Article

Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

Journal Article

Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372

BAI Xiangyang, TANG Duozhuang, ZHU Tao, SUN Lishi, YAN Lingling, LU Yunping, ZHOU Jianfeng, MA Ding

Journal Article

FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OFTHE FNC GENE

Journal Article

Engineering the grain boundary: a promising strategy to configure NiCoPO/NiCoP nanowire arrays for ultra-stable

Journal Article

Erratum to: Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen

Shenghua Ye, Gaoren Li

Journal Article

Tuning the electronic structure of NiCoP arrays through V doping for pH-universal hydrogen evolution

Yu Lin, Jinlei Wang, Duanlin Cao, Yaqiong Gong

Journal Article

Nickel nanopore arrays as promising current collectors for constructing solid-state supercapacitors with

Huaping Zhao, Long Liu, Yaoguo Fang, Ranjith Vellacheri, Yong Lei

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Construction of NiCoO nanoflake arrays on cellulose-derived carbon nanofibers as a freestanding electrode

Journal Article

Fluorescent probes and functional materials for biomedical applications

Journal Article

Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen evolution reaction

Shenghua Ye, Gaoren Li

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

A post-GWAS replication study confirming the association of

Shaohua YANG,Chao QI,Yan XIE,Xiaogang CUI,Yahui GAO,Jianping JIANG,Li JIANG,Shengli ZHANG,Qin ZHANG,Dongxiao SUN

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article